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Publications

Publications by RadCCORE members

In Press, not yet indexed:

Berbee M, Fu Q, Boerma M, Wang J, Kumar KS, Hauer-Jensen M: Gamma-tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total body irradiation by an HMG-CoA reductase-dependent mechanism. Radiat Res, in press.

Fu Q, Berbee M, Boerma M, Wang J, Schmid HA, Hauer-Jensen M: The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total body irradiation by inhibiting exocrine pancreatic secretion. Radiat Res, in press.

Sheng, H., Sakai, H., Yang, W., Fukuda, S., Salahi, M., Day, B. J., Huang, J., Paschen, W., Batinic-Haberle, I., Crapo, J. D., Pearlstein, R. D., Warner, D. S. Sustained treatment is required to produce long-term neuroprotective efficacy from a metalloporphyrin catalytic antioxidant in focal cerebral ischemia, Free Radic. Biol. Med 2009, in press.

BradySL, Toncheva G, Dewhirst MW, and YoshizumiTT. Characterization of a ¹³⁷Cs Irradiator from a New Perspective with Modern Dosimetric Tools. Health Physics 2009 (In press).

Peer Reviewed Publications

1. Zhao, C., et al., Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature, 2009. 458(7239): p. 776-9.

2. Wise-Faberowski, L., et al., Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. Free Radic Res, 2009. 43(4): p. 329-39.

3. Salter, A.B., et al., Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. Blood, 2009. 113(9): p. 2104-7.

4. Safi, R., et al., Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Mol Endocrinol, 2009. 23(2): p. 188-201.

5. Pollard, J.M., et al., Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells. Free Radic Biol Med, 2009.

6. Kos, I., et al., Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free Radic Biol Med, 2009. 47(1): p. 72-8.

7. Kodell, R.L., et al., Determination of Sample Sizes for Demonstrating Efficacy of Radiation Countermeasures. Biometrics, 2009.

8. Batinic-Haberle, I., et al., Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. Free Radic Biol Med, 2009. 46(2): p. 212-9.

9. Batinic-Haberle, I., et al., Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med, 2009. 46(2): p. 192-201.

10. Allen, I.C., et al., The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity, 2009. 30(4): p. 556-65.

11. Ye, Z., et al., ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol, 2008. 28(5): p. 1841-50.

12. Weinstock, D.M., et al., Radiologic and nuclear events: contingency planning for hematologists/oncologists. Blood, 2008. 111(12): p. 5440-5.

13. Spasojevic, I., et al., Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. Free Radic Biol Med, 2008. 45(7): p. 943-9.

14. Reboucas, J.S., et al., Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution. Dalton Trans, 2008(9): p. 1233-42.

15. Reboucas, J.S., I. Spasojevic, and I. Batinic-Haberle, Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology. J Biol Inorg Chem, 2008. 13(2): p. 289-302.

16. Reboucas, J.S., I. Spasojevic, and I. Batinic-Haberle, Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. J Pharm Biomed Anal, 2008. 48(3): p. 1046-9.

17. Reboucas, J.S., et al., Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. Free Radic Biol Med, 2008. 45(2): p. 201-10.

18. Meadows, S.K., et al., Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One, 2008. 3(4): p. e1912.

19. Kurokawa, M., et al., Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol, 2008. 28(17): p. 5494-506.

20. Hart, J.P., et al., Radiation pneumonitis: correlation of toxicity with pulmonary metabolic radiation response. Int J Radiat Oncol Biol Phys, 2008. 71(4): p. 967-71.

21. Gauter-Fleckenstein, B., et al., Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med, 2008. 44(6): p. 982-9.

22. DeFreitas-Silva, G., et al., SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself. Arch Biochem Biophys, 2008. 477(1): p. 105-12.

23. De Lin, M., et al., Application of MOSFET detectors for dosimetry in small animal radiography using short exposure times. Radiat Res, 2008. 170(2): p. 260-3.

24. Congdon, K.L., et al., Activation of Wnt signaling in hematopoietic regeneration. Stem Cells, 2008. 26(5): p. 1202-10.

25. Congdon, K.L. and T. Reya, Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. Curr Opin Immunol, 2008. 20(3): p. 302-7.

26. Blakaj, A. and H. Lin, Piecing together the mosaic of early mammalian development through microRNAs. J Biol Chem, 2008. 283(15): p. 9505-8.

27. Batinic-Haberle, I. and L.T. Benov, An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. Free Radic Res, 2008. 42(7): p. 618-24.

28. Zhao, Y., et al., Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol, 2007. 27(12): p. 4328-39.

29. Zhao, C., et al., Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell, 2007. 12(6): p. 528-41.

30. Wu, M., et al., Imaging hematopoietic precursor division in real time. Cell Stem Cell, 2007. 1(5): p. 541-54.

31. Spasojevic, I., et al., Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria. Free Radic Biol Med, 2007. 42(8): p. 1193-200.

32. Moore, C.B., et al., Downregulation of immune signaling genes in patients with large surface burn injury. J Burn Care Res, 2007. 28(6): p. 879-87.

33. Lahaye, D., et al., Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. Bioorg Med Chem, 2007. 15(22): p. 7066-86.

34. Duncan, J.A., et al., Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proceedings of the National Academy of Sciences of the United States of America, 2007. 104(19): p. 8041-6.

35. Dressman, H.K., et al., Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med, 2007. 4(4): p. e106.

36. Chute, J.P., et al., Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood, 2007. 109(6): p. 2365-72.

37. Al-Mutairi, D.A., et al., Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin. Free Radic Res, 2007. 41(1): p. 89-96.

38. Al-Mutairi, D.A., et al., Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin. Biochim Biophys Acta, 2007. 1770(11): p. 1520-7.

39. Weisdorf, D., et al., Acute radiation injury: contingency planning for triage, supportive care, and transplantation. Biol Blood Marrow Transplant, 2006. 12(6): p. 672-82.

40. Muramoto, G.G., et al., Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury. Biol Blood Marrow Transplant, 2006. 12(5): p. 530-40.

41. Clements, C.M., et al., DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proceedings of the National Academy of Sciences of the United States of America, 2006. 103(41): p. 15091-6.

42. Batinic-Haberle, I., et al., New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme. Dalton Trans, 2006(4): p. 617-24.

43. Al-Mutairi, D.A., et al., Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells. Free Radic Res, 2006. 40(5): p. 477-83.

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